Interact with the image to see before and after.
Close
Figure 1: Nuclei (blue) with cell cycle marker (red) DNA damage foci (green).
Figure 2: Segmented nuclei (cyan highlights) and segmented foci (magenta highlights) within each nucleus.
The solution allows for fast and flexible stratification of nuclei according to a diverse array of parameters for an in-depth mechanistic analysis of genotoxicity. Once set up, such an analysis can easily be scaled up to hundreds of samples.
Figure 3: Scatter plot showing DNA damage marker intensity (EdU) over DAPI intensity for each nucleus. Expected values for different cell cycle phases are highlighted in red.
