DRUG DISCOVERY

HIGH CONTENT SCREENING & ANALYSIS

Research Processes

Scaling up Innovation

High-Content Screening (HCS) has played a significant role in infectious disease research and drug discovery to date and can be a strong tool in the age of COVID-19 and beyond. With a focus on viral diseases, HCS has been used by laboratories around the world to help with three key interventional strategies: drug re-purposing to fast-track a previously-approved drug to treat new diseases; development of new therapeutics; and vaccine development.

High-Content Analysis for Complex Biology

In contrast to the luxury of screening against a critical single target protein, many of the complex diseases that you need to screen drugs against require a broader view of cell or tissue phenotype. This has led to a significant shift towards multi-dimensional High-Content Analysis (HCA) with spheroids, organoids or tumoroids. There are new and emerging important applications involving High-Content Screening that require sophisticated image analysis methods, scalable from 2D to 3D and even 4D.

The arivis Scientifc Imaging Platform allows for highly scalable and automated assay analysis pipelines on the local workstation as well as server-based or cloud-based processing services. Fully integrated workflows for AI methods such as Machine Learning and Deep Learning can save valuable time for recurring and reproducible imaging analysis tasks. Large data sets from past experiments have typically been safely archived and can be re-analyzed with these new methods to generate new discoveries, thanks to the compatibility with multiple vendor-specific file formats.

infographic-hts

 

High-Content Imaging & Analysis

HCS_HCA_ZEISS_arivis_pharma_drug_discovery_infochart

 

1
Integration Flexible integration of robotics and external hardware via instrument manufacturer APIs.
2
High-content Imaging High-content imaging with manufacturer acquisition software and transfer into the arivis Scientific Imaging Platform.
3
Local HCA & AI Workstation-based imaging assays with powerful Vision4D analysis pipelines for rapid insights.
4
Server HCA & AI Scalable, server-based high-performance analysis, remote access and collaboration with VisionHub.

Computing Infrastructure

arivis VisionHub is a highly scalable and customizable solution that can be adopted to a wide variety of existing data storage and processing infrastructure, from single department and core facility to campus-wide deployment and distributed data centers for multiple locations in pharma industry. However, there is a rising need for out-of-the-box solutions for image storage and processing particularly for small to mid-size businesses such as startups in biotech, CRO, or newly established academia spin-offs that require cost-efficient, modular solutions with minimal administrative hassles.

This is why arivis recommends the HIVE® modular server platform by ACQUIFER™ for rapid and efficient VisionHub deployment. Designed for the pragmatic, biology-focused scientist, the HIVE platform boosts productivity in microscopy facilities and screening labs. HIVE is a high speed centralized data repository that removes the need to constantly move or duplicate data sets in processing and analysis workflows. Its modular design integrates high speed processing, visualization, remote access, project management, flexibility, data security, scalability and ease of use in one unit.

It saves time, space, costs and administrator workload.

 

INDUSTRIES

Biotech

Modern usage of 3D cell and tissue culture technology are these days used more frequently to work with  living organism. 3D cell cultures today already are used instead of using expensive animal models. To view and analyse these complex structures Arvis has been developing over the last decade tools to help scientists to act faster and more accurate.

Pharma

Today discover, develop and produce drugs are becoming time critical for the success of a whole industry sector. Arivis and it’s TEAM is helping to shorten the evaluation of a new drug by delivering professional, scalable software solution to analyse and view complex imaging datasets

CRO

Contract research organisation provide to Pharmaceutical, biotechnology and medical device industry their outsourced services. To share efficient imaging results with their industry partner CRO often need to collaborate with their partner. Arivis 3D viewing and analysis software helps researchers to be more efficient in research process and collaborate their complex imaging results faster

CMO

Contract manufacturing organization needs professional and scalable imaging analysis solution in order to guaranty the quality level for Pharmaceutical industry will need today. To obtain this quality Arivis AG has developed imaging analysis tools to fulfil this high demand in imaging and Industry standards in QC/QA.

gallery-03

CONTACT US

For further information please contact us, we look forward to hearing from you.

Get in Contact

arivis-Vision4D

teaser-Vision4D

Your modular software toolkit for extracting results from scientific images. Adjusts to hardware for maximum power and smooth interactivity on microscopy datasets of virtually unlimited size. Vision4D unites multiple tools for visualization and advanced analysis into one easy-to-learn user environment for highly productive productive workflows. Extend your possibilities directly via Python and connect to a multitude of applications via supported libraries and APIs.

Advanced AI analysis 
Machine Learning & Deep Learning Workflows
Tile Stitching
4D Tracking & Lineage
Data Transformation
Segmentation
Image Preprocessing & Enhancement
Interactive rendering of volumes and time-series
Cinematic high-resolution rendering
Batch application of Analysis Pipelines
Custom Computed Features of Objects
Exploration of Results overlaid on raw data

arivis-VisionVR

teaser-VisionVR

Display real image data in Virtual Reality by utilizing patent pending direct volume rendering techniques with no need to convert data or make surface models. Directly use your hands to move, rotate, scale, and shape your digital image data. Interactively proofread, edit, track or segment multi-dimensional images from any microscopy technology. Perform productive and collaborative work in a truly immersive environment.

 

Smooth Rendering and Visualization
Best-in-class hardware support with OpenXR API
Collaboration via different VR Scenarios
Direct Volume Rendering
Productive workflows for faster results

Navigation in immersive Environment

Export Snapshots, Movies and 360°
Seamless Exchange with Desktop Application
Sculpting Tools to Add, Delete and Proof-read
Magic Wand Tools

arivis-VisionHub

teaser-VisionHub

A nucleus of computational activity and collaboration at scale. VisionHub enables design and execution of large-scale experiments that produce results from images, whether datasets are already stored or are actively being produced. Mass quantities of microscopy data are onboarded and processed by a virtual team of computational workers. Smartly utilize processing cores in servers or workstations with the maximum speeds possible.

Register and browse image and data
Manage access for users and groups
Import and archive datasets into the arivis framework
Create experiments that produce results at scale
Leverage computational resources onsite and offsite
Scalable pricing model to support bursts of throughput
Visualize massive image volumes via remote rendering servers
Implement quality checks for increased efficiency and validity
Smart optimization of parallelization

RESOURCES