DRUG DISCOVERY

DRUG DISCOVERY

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How new medications are discovered

Drug discovery is the process how new medications are discovered. In history, drugs were mostly found by identifying active ingredients from traditional medicines or purely by chance. Afterward, classical pharmacology was used to investigate chemical libraries including small molecules, natural products, or plant extracts, and find those with therapeutic effects. Since human DNA was sequenced, reverse pharmacology has found remedies to existing diseases through testing.


Disease processes, molecular compound tests, existing treatments with unanticipated effects, and new technologies spur drug discovery through the cycle below.

Today drug discovery involves screening hits, medicinal chemistry, and optimization of hits to reduce potential drug side effects (increasing affinity and selectivity). Efficacy or potency, metabolic stability (half-life), and oral bioavailability are also improved in this step of the drug development process.

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High Content Screening (HCS)

High content screening (HCS) has played a significant role in infectious disease research and drug discovery to date and can be a strong tool in the age of COVID-19 and beyond.

With a focus on viral diseases, HCS has been used by laboratories around the world to help with three key interventional strategies:

HIGHLIGHTS

  • Drug re-purposing to fast track previously approved drug to treat new diseases
  • Development of new therapeutics and
  • Vaccine development.
 

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Image Annotation Workflow

With the development of diagnostic imaging devices, large amounts of digital high-res and 3D images are generated every day. The requirements of effective indexing and searching image are growing rapidly. Image annotation is an effective way for content-based image retrieval.

HIGHLIGHTS

  • Semi-Automatic operator supported models
  • Automatic annotations with AI
  • Manual annotation (remote, mobile devices)
 

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Remote Image Analysis

When researchers start to collaborate over distances with imaging centers, using diagnostic services over internet connections the bandwidth and computation power easily exceeds the capabilities in remote areas.

HIGHLIGHTS

  • 3D organotypic culture models
  • Microplates
  • Automation and liquid handling
  • 3D imaging
  • 3D image analysis
 

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Laboratory RAW Data Management

RAW DATA in laboratories occur in various fluctuating formats and versions in a large amount of laboratory devices, LIMS and quality management systems. Handling and traceability along the whole life cycle are key to lab control and end-to-end compliance in the drug development process.

HIGHLIGHTS

  • OOS Tracking
  • Archiving
  • Long term file formats
 

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CRO Collaboration

The last few years have seen tremendous consolidation in both the pharmaceutical and contract research industries. The impact among pharma companies has created a heightened demand for productivity. Properly designed CRO Collaboration opens capabilities in various functions like the following:

HIGHLIGHTS

  • Pharmacovigilance
  • Medical Writing
  • Statistical Programming
  • Site Management
  • Regulatory Affairs
  • Regulatory Operations
  • Biostatistics
  • Data Management
  • Translational Medicine
  • Medical Affairs
  • Clinical Monitoring
 

arivis5D Platform

arivis5D-imaging

product-image-arivis5D-imaging

Comprehensive Imaging Science solution for research and production imaging processes.  Process support that covers the whole workflow from imaging to conclusions. Improve and integrate image production, data ingestion/archiving, storage, access, analysis strategy, QA/QC, computation at scale, review of results, and implementation of custom algorithms and AI.

Configurable by subject matter experts
Scripting interfaces
Workflows for optimization at every step
Accelerated computation for projects
Results in space and time on image volumes
Access any portion of image at any time
Connect datasets & results across projects

arivis5D Platform

arivis5D-compliance

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Quality Management System with features to secure and control data & documents. Collaborative platform for regulated content, processes and end-to-end compliance along the complete life sciences life cycle. Powerful and intuitive navigation, enhanced user experience, dynamic content management and search features. Connecting quality teams globally.

Controlled assets and documents
Collaborative platform for regulated content
Processes and end-to-end compliance
Workflows along the complete life sciences life cycle

arivis5D Platform

arivis5D-protocol

product-image-arivis5D-protocol

Trial Master File solution to securely review and audit TMF documentation. Digital process support with form-based workflow for the complete (pre-) clinical document processes. Visualize real-time completeness based on study, country and site indicators. Apply filters and different dimensions, view metadata to intuitively navigate through complex eTMF filings

Audit savvy Trial Master File solution 
Digital and process centric approach
Real-time indicators on all levels
Intuitive navigation in various dimensions based on metadata
Fully integrated with CTMS workflow events and triggers

arivis5D Platform

arivis5D-information

product-image-arivis5D-information

Document and project management solution for life science. Tools for operations and oversight teams to prepare and review documents and records for the completion and successful submissions and correspondence. User centric collaboration, automation and quality workflows featuring the life cycle of documents and dossiers from authoring to (re-) submission.

Document, asset- and project management
Operations and oversight
Collaborative review for submissions and correspondence
Automation and quality workflows from authoring to (re-) submission

arivis5D Platform

arivis5D-rawdata

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arivis BM-Watcher is a 21 CFR Part 11 raw data management solution for the pharmaceutical industry.  It integrates with nearly all types of laboratory instruments. It is able to provide data integrity features even for legacy systems. arivis BM-Watcher is an agent that is able to monitor the file storage of a laboratory device. 

Access control
Audit trails
File versions
Electronic signature Lifecycle
Automated indexing of all data
Integr. electr. long term archive
Instrument monitoring

On Premise

BM-Flow

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Complete document management, training management, CAPA, deviations, change control - all in one tool.

Inbox for all types of tasks: documents, QA processes, training
Configurable document workflows
Configurable forms, workflows and reports for CAPA, deviations, change control (and many more)
Digital signatures - certificate based. No third-party tools required.
Training plans, training organization, reports on trainings
Quiz module

On Premise

BM-Watcher

product-image-BM-Watcher

arivis BM-Watcher is a 21 CFR Part 11 raw data management solution for the pharmaceutical industry.  It integrates with nearly all types of laboratory instruments. It is able to provide data integrity features even for legacy systems.

Access control
Audit trails
File versions
Electronic signature Lifecycle
Automated indexing of all data
Integr. electr. long term archive
Instrument monitoring

arivis-Vision4D

teaser-Vision4D

Modular software toolkit for extracting results from scientific images. Adjusts to hardware for maximum power and smooth interactivity on image datasets of unlimited size. Brings diverse tools into one environment and enables users to connect them into productive workflows. Highly interactive for optimization and quality at every step. Extendible directly via Python and connectable to other applications via libraries.

Tile Stitching
Data Transformation
Image Preprocessing & Enhancement
Segmentation
4D Tracking & Lineage
Batch application of Analysis Pipelines
Custom Computed Features of Objects
Exploration of Results overlaid on raw data
Interactive rendering of volumes and time-series
Cinematic high-resolution rendering

arivis-VisionVR

teaser-VisionVR

Display real image data in Virtual Reality by utilizing patent pending direct volume rendering techniques with no need to convert data or make surface models. Directly use your hands to move, rotate, scale, and shape your digital image data. Interactively proofread, edit, track or segment multi-dimensional images from nearly any source instrument.

 

Smooth Rendering and Visualization
Collaboration via different VR Scenarios
Direct Volume Rendering
Export Snapshots, Movies and 360°
Seamless Exchange with Desktop Application
Sculpting Tools to Add, Delete and Proof-read
Magic Wand Tools

arivis-VisionHub

teaser-VisionHub

A nucleus of computational activity and collaboration at scale. VisionHub enables design and execution of large-scale experiments that produce results from images, whether datasets are already stored or are actively being produced. Mass quantities of Imagery are onboarded and processed by a virtual team of computational workers. Smartly utilize processing cores in servers or workstations with the maximum speeds possible.

Register and browse image and data
Manage access for users and groups
Import and archive datasets into the arivis framework
Create experiments that produce results at scale
Leverage computational resources onsite and offsite
Scalable pricing model to support bursts of throughput
Visualize massive image volumes via remote rendering servers
Implement quality checks for increased efficiency and validity
Smart optimization of parallelization

CUSTOMERS

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“ The only way to discover the limits of the possible is to go beyond them into the impossible.”