arivis as project partner in the 3D-Tissue Screen

colored cardiac muscle cells,
acquired with the 3D-microscopy platform
and visualized by the arivis browser
(source: Saarland University, MCB)

In November 2009 a project status report of joined partners from industry and science was published in the media.
The research group “3D-Tissue Screen”, which is promoted by the BMBF in the field of biophotonics, has developed a live-cell microscope which allows the fastest monitoring of dynamic processes in cardiac muscle cells so far.
This microscope technology provides the basis for further research on cardiac arrhythmia and Alzheimer’s disease and makes it possible to study cells and their internal processes in a natural environment.
A prototype of the new 3D reader platform allows to keep living cells in special cell chambers in their natural, three-dimensional environment, to influence them and to exactly study and visualize their behavior.
Since commercial microscopes haven’t been suitable for automated high-throughput applications in life cell research, the joined partners have examined and validated several concepts which now form the basis for the 3D reader platform.
The concept is optimized for high performance analysis and combines different microscopic methods, from laser scanning to fluorescence life time measuring to digital holography.

Furthermore, the joined partners researched on additional applications of the new technology like the two photon endoscopy for intraoperative tissue diagnostics as well as the examination of plant root cells for an eco-friendly pest control.

Business partners in this project are:

TILL Photonics GmbH/TOPTICA Photonics AG aus Gräfelfing
arivis - Multiple Image Tools GmbH aus Rostock
ibidi GmbH aus München
PicoQuant GmbH aus Berlin

Academic partners are:

Centrum für Biomedizinische Optik und Photonik (CeBOP) an der Universität Münster
BioImaging Zentrum (Biz) und das Zentrum für Neuropathologie und Prionforschung der LMU München
LIFE-Zentrum des Universitätsklinikums München
Institut für Molekulare Zellbiologie der Universität des Saarlandes
Zentrum für Angewandte Biowissenschaften der Albert-Ludwigs-Universität Freiburg